We analyzed the effects of fish oil lipid emulsion on the prevention of deep vein thrombosis in children with intestinal failure.
In this study, we compared 35 pediatric patients receiving a soy oil lipid emulsion with 35 who received fish oil.
Remarkably, none of the children in the fish oil group experienced blood clots, whereas the soy oil group had ten cases. This suggests that fish oil lipid emulsion may significantly reduce the risk of clots associated with central venous catheters.
Read More
9
Omega-3 reduces clot risk post-surgery
Omega-3 fatty acids reduce post-operative risk of deep vein thrombosis and pulmonary embolism after surgery for elderly patients with proximal femoral fractures: a randomized placebo-controlled, double-blind clinical trial.
We explored the impact of omega-3 fatty acids on blood clot risks in elderly patients recovering from proximal femoral fractures after surgery. In a randomized, double-blind study involving 452 participants, those who received daily supplementation of 1000 mg of omega-3 for 30 days experienced significant reductions in pulmonary embolism and symptomatic deep vein thrombosis compared to those on a placebo. Importantly, these benefits came without an increased risk of bleeding complications.
Read More
9
FJH-KO reduces blood clots
Antarctic Krill Oil from Ameliorates Carrageenan-Induced Thrombosis in a Mouse Model.
We investigated the impact of FJH-KO, a source of omega-3 fatty acids from Antarctic krill, on thrombosis in a mouse model. By inducing thrombosis using carrageenan, we treated the mice with FJH-KO beforehand.
The results showed that FJH-KO reduced thrombus formation and prolonged bleeding time. It also lowered levels of substances associated with clotting while boosting protective factors. Additionally, in human cells, FJH-KO inhibited the adhesion of immune cells, suggesting its potential as an antithrombotic agent.
Read More
Most Useful Reviews
7.5
Improves overall health.
120 people found this helpful
This Omega-3 formulation is exceptional, with high EPA and DHA content. Taking just one capsule daily prevents fishy burps and allergies. It enhances immunity, alleviates anxiety, and strengthens my heart and blood vessels. Regular intake has remarkably improved my quality of life.
Read More
9
Reduces blood clot risks.
32 people found this helpful
Omega-3 has numerous benefits, including reducing blood clot risks and cholesterol levels. This helps restore vascular health and supports brain function. A deficiency can lead to dry skin and anxiety. This specific Omega has added vitamin D3, enhancing its beneficial properties greatly.
Read More
9
Heart and mind wellness
9 people found this helpful
Great OMEGA 3 from Now Foods is beneficial for heart, blood vessels, brain, joints, and vision. The dose of fatty acids combined with vitamin D3 supports overall health. I take Omega-3 regularly in the mornings with a fat-containing meal. It’s remarkable quality that I recommend for anyone concerned with their health.
We analyzed the effects of fish oil lipid emulsion on the prevention of deep vein thrombosis in children with intestinal failure.
In this study, we compared 35 pediatric patients receiving a soy oil lipid emulsion with 35 who received fish oil.
Remarkably, none of the children in the fish oil group experienced blood clots, whereas the soy oil group had ten cases. This suggests that fish oil lipid emulsion may significantly reduce the risk of clots associated with central venous catheters.
Read More
9
FJH-KO reduces blood clots
Antarctic Krill Oil from Ameliorates Carrageenan-Induced Thrombosis in a Mouse Model.
We investigated the impact of FJH-KO, a source of omega-3 fatty acids from Antarctic krill, on thrombosis in a mouse model. By inducing thrombosis using carrageenan, we treated the mice with FJH-KO beforehand.
The results showed that FJH-KO reduced thrombus formation and prolonged bleeding time. It also lowered levels of substances associated with clotting while boosting protective factors. Additionally, in human cells, FJH-KO inhibited the adhesion of immune cells, suggesting its potential as an antithrombotic agent.
Read More
9
DHA's role in blood clotting
DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway.
We investigated how docosahexaenoic acid (DHA) and its derivatives affect platelet activity and blood clotting. Our findings revealed that DHA, along with its oxidized forms, effectively reduced platelet aggregation and activation, particularly in mouse models.
Although DHA showed some benefits, the most significant effects on blood clots came from its oxylipins, specifically 11-HDHA and 14-HDHA. These compounds appeared to inhibit platelet adhesion and thrombus formation through a specific signaling pathway, enhancing the potential for DHA as a treatment for clot-related cardiovascular issues.
Read More
9
Omega-3 reduces clot risk post-surgery
Omega-3 fatty acids reduce post-operative risk of deep vein thrombosis and pulmonary embolism after surgery for elderly patients with proximal femoral fractures: a randomized placebo-controlled, double-blind clinical trial.
We explored the impact of omega-3 fatty acids on blood clot risks in elderly patients recovering from proximal femoral fractures after surgery. In a randomized, double-blind study involving 452 participants, those who received daily supplementation of 1000 mg of omega-3 for 30 days experienced significant reductions in pulmonary embolism and symptomatic deep vein thrombosis compared to those on a placebo. Importantly, these benefits came without an increased risk of bleeding complications.
Read More
8
Omega-3s reduce blood clot risk
Dietary n-3 polyunsaturated fatty acids alter the number, fatty acid profile and coagulatory activity of circulating and platelet-derived extracellular vesicles: a randomized, controlled crossover trial.
We examined how fish oil, rich in omega-3 polyunsaturated fatty acids (PUFAs), impacts blood clotting in individuals at moderate risk for cardiovascular diseases. In a controlled study with 40 participants, we discovered that fish oil supplementation led to significant changes in circulating extracellular vesicles (EVs), which are linked to clotting processes.
Notably, the fish oil reduced the coagulatory activity of these EVs, suggesting a protective effect against thrombus formation. This finding opens up new avenues for preventing blood clots and managing cardiovascular health.
This Omega-3 formulation is exceptional, with high EPA and DHA content. Taking just one capsule daily prevents fishy burps and allergies. It enhances immunity, alleviates anxiety, and strengthens my heart and blood vessels. Regular intake has remarkably improved my quality of life.
Read More
9
Reduces blood clot risks.
32 people found this helpful
Omega-3 has numerous benefits, including reducing blood clot risks and cholesterol levels. This helps restore vascular health and supports brain function. A deficiency can lead to dry skin and anxiety. This specific Omega has added vitamin D3, enhancing its beneficial properties greatly.
Read More
9
Heart and mind wellness
9 people found this helpful
Great OMEGA 3 from Now Foods is beneficial for heart, blood vessels, brain, joints, and vision. The dose of fatty acids combined with vitamin D3 supports overall health. I take Omega-3 regularly in the mornings with a fat-containing meal. It’s remarkable quality that I recommend for anyone concerned with their health.
Read More
9
Improved cholesterol levels
4 people found this helpful
I'm extremely pleased with Omega 3, though it occasionally runs out of stock, requiring a wait. It features maximum polyunsaturated acids with a rare ratio, plus vitamin D. I consume two capsules daily. My blood became more liquid (the heat no longer bothers me). Cholesterol levels returned to normal.
Read More
9
Improves blood count.
3 people found this helpful
My favourite supplement! It has the ideal price-quality ratio. Despite not enjoying fish, this supplement has been a game changer. I've seen significant improvements in my blood pressure and overall blood counts. No unpleasant aftertaste, just a great way to meet my dietary needs!
A blood clot is a mass of blood that changes from a liquid to a gel, effectively forming a plug that can stop bleeding. This natural process, known as coagulation, is critical for preventing excessive blood loss when you sustain an injury. Blood clots can occur in various areas of the body, typically at the site of a wound, but they can also form within blood vessels without an obvious injury, which may lead to serious health complications.
While blood clots are essential for healing, they can pose significant health risks if they form inappropriately. For example, a deep vein thrombosis (DVT) occurs when a clot forms in a deep vein, usually in the legs, and can travel to the lungs, causing a life-threatening condition called a pulmonary embolism. Risk factors for blood clots include prolonged immobility, certain medical conditions, and the use of specific medications, among others. It’s important to recognize the symptoms of abnormal clotting, such as swelling, pain, and redness in the affected area, and seek medical attention if they occur.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil is often touted for its cardiovascular benefits, but its relationship with blood clots is nuanced. The omega-3 fatty acids found in fish oil, particularly EPA and DHA, can help reduce inflammation and have been shown to have a mild blood-thinning effect. This may be beneficial for individuals at risk of heart disease, as it can help improve blood circulation and reduce the formation of clots. However, this doesn't mean that fish oil is a substitute for prescribed anticoagulant medications or that it can prevent blood clots entirely.
It's essential to consult a healthcare professional before incorporating omega-3 fish oil into your routine, especially if you're on blood-thinning medications or have existing health conditions. While some studies suggest that higher intakes of omega-3s can support cardiovascular health, the effects can vary based on individual health factors. Always prioritize informed medical advice to tailor supplementation to your unique health profile.
Based on user reviews, individuals taking Omega-3 supplements for blood clot concerns report varying timelines for noticing results. Some users mention significant improvements in their blood pressure and overall blood counts after just a couple of months of regular intake Read Review. In particular, one user experienced a threefold decrease in blood triglyceride levels after a similar duration Read Review.
Additionally, users have reported noticeable benefits on their blood viscosity and cholesterol levels within a few weeks Read Review, suggesting that while immediate effects may vary, consistent usage over a couple of months generally yields positive results. Many recommend taking the supplements alongside meals to enhance absorption Read Review. Overall, it's often suggested that users should allow at least a month or two to fully appreciate the cardiovascular benefits of Omega-3 supplements.
The connection between omega-3 fatty acids and blood clot prevention is supported by a substantial body of scientific research. Studies have demonstrated that fish oil, which is rich in omega-3s, can lead to significant changes in coagulatory activity. For example, one study found that fish oil supplementation reduced the coagulatory activity of extracellular vesicles, indicating a protective effect against blood clot formation ([1]). Another investigation revealed that higher levels of omega-3s were associated with lower markers of coagulation in patients with atrial fibrillation, suggesting potential benefits in reducing blood clot risks ([2]).
Moreover, research on Antarctic krill oil, a source of omega-3s, demonstrated a reduction in thrombus formation and a longer bleeding time, highlighting its potential as an antithrombotic agent ([3]). Noteworthy findings also include a trial that indicated elderly surgery patients who received omega-3 supplementation experienced fewer instances of pulmonary embolism and deep vein thrombosis without an increased risk of bleeding ([6]). Collectively, these studies point to omega-3 fatty acids as promising supplements for managing blood clot risks, especially in specific populations at higher risk.
Based on user reviews, many individuals taking Omega-3 supplements report beneficial improvements in various health parameters, particularly related to cardiovascular and mental wellness. Users have noted significant enhancements in blood pressure, with some experiencing noticeable decreases after just a few months of regular use, contributing to overall vascular health Read Review. Others have highlighted the positive effects on blood viscosity and cholesterol levels, crediting the formulation with helping to cleanse blood vessels of excess "bad" cholesterol and thereby preventing serious conditions like strokes and heart attacks Read Review.
Anecdotal experiences also suggest that the cognitive benefits of Omega-3 are notable, with users reporting improved mental clarity and focus, beneficial for those engaged in intellectually demanding tasks. Some individuals have gone so far as to describe life transformations related to energy increases and improved immune resistance stemming from their Omega-3 intake Read Review. While individual results can vary, the consensus among reviews suggests a general pattern of positive health improvements with consistent Omega-3 supplementation.
Based on user reviews, many individuals report positive experiences when combining Omega-3 supplements with other dietary aids. Several users have specifically mentioned taking Omega-3 alongside vitamin D3, noting that this combination not only enhances the benefits but also improves overall health outcomes related to blood viscosity and heart health Read Review. One user even highlighted achieving significant reductions in blood triglyceride levels while regularly using Omega-3 with vitamin D Read Review.
Additionally, some users suggest that incorporating Omega-3 with a fatty meal further aids in absorption and efficacy, thereby maximizing its health benefits Read Review. Other anecdotal reports indicate that individuals who alternate different formulations of Omega-3 feel more effective psychologically and physically Read Review. Overall, the consensus among reviews indicates that, when combined thoughtfully with other supplements, Omega-3 can significantly enhance cardiovascular health and improve blood circulation.
When it comes to the optimal dose of Omega-3 Fish Oil for treating blood clots, research suggests a daily supplementation of around 1,000 mg may provide significant benefits without increasing the risk of bleeding complications. In a well-controlled study involving elderly surgery patients, those receiving this dosage experienced notable reductions in the incidence of pulmonary embolism and symptomatic deep vein thrombosis compared to those on a placebo, highlighting the potential of Omega-3s as a protective agent against thrombus formation [6]. Similar findings have been reported in other studies, suggesting that daily doses of Omega-3s can lower clotting risks by influencing various clotting markers, thereby promoting better cardiovascular health [2].
Additionally, it's worth noting that Omega-3s, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are known to modulate platelet activity and thrombin generation, which are critical factors in the clotting process. While individual responses can vary, a consistent intake of around 1,000 mg per day appears to align with the most favorable outcomes observed in both clinical and experimental settings [16]. That said, before making any alterations to your supplementation routine, it's advisable to consult with a healthcare professional, particularly for those on anticoagulant therapy or with specific medical conditions.
9
Heart and mind wellness
9 people found this helpful
Great OMEGA 3 from Now Foods is beneficial for heart, blood vessels, brain, joints, and vision. The dose of fatty acids combined with vitamin D3 supports overall health. I take Omega-3 regularly in the mornings with a fat-containing meal. It’s remarkable quality that I recommend for anyone concerned with their health.
9
Lowered triglyceride levels
2 people found this helpful
I take omega-3s to reduce blood triglyceride levels. After a couple of months, I experienced a threefold decrease—an excellent result. I intend to continue. The golden transparent capsules are large but swallowable. I take two before bed, along with vitamin D.
9
Normalised blood pressure
3 people found this helpful
Omega-3 acids effectively "cleanse" blood vessels of excess "bad" cholesterol, preventing "cholesterol plaques". It improves blood viscosity and regulates blood pressure while increasing levels of "good" cholesterol - HDL. It strengthens blood vessel walls, enhancing their elasticity.
9
Supports blood vessels.
1 people found this helpful
Omega-3 helps maintain blood vessel elasticity and reduces plaque buildup, crucial at my age. It aids in normal blood pressure levels and triglycerides, with excellent anti-inflammatory properties. Despite the capsules being hard to swallow, I drink them during a fatty meal, which enhances absorption. The taste is delightful—slightly lemony.
9
Improves blood count.
3 people found this helpful
My favourite supplement! It has the ideal price-quality ratio. Despite not enjoying fish, this supplement has been a game changer. I've seen significant improvements in my blood pressure and overall blood counts. No unpleasant aftertaste, just a great way to meet my dietary needs!
9
Enhanced energy levels
3 people found this helpful
Ultra Omega 3 has transformed our lives significantly. As we age, this supplement helps boost our energy and bolster our resistance against infections. Our blood tests show improved clinical results, markedly reducing blood pressure and heart issues. We clearly notice enhancements in mental clarity and focus, crucial for our intellectual work. The price and packaging are also appealing.
9
Reduces blood clot risks.
32 people found this helpful
Omega-3 has numerous benefits, including reducing blood clot risks and cholesterol levels. This helps restore vascular health and supports brain function. A deficiency can lead to dry skin and anxiety. This specific Omega has added vitamin D3, enhancing its beneficial properties greatly.
7.5
Great value product
1 people found this helpful
I recommend carefully comparing the Omega 3 content against other products and opting for one with a high concentration. While not the highest quality, it offers good value for money at the upper mid-level. Regular consumption is believed to greatly benefit blood circulation. I alternate with a DHA-fortified product and feel psychologically more effective.
8
Omega-3s reduce blood clot risk
Dietary n-3 polyunsaturated fatty acids alter the number, fatty acid profile and coagulatory activity of circulating and platelet-derived extracellular vesicles: a randomized, controlled crossover trial.
We examined how fish oil, rich in omega-3 polyunsaturated fatty acids (PUFAs), impacts blood clotting in individuals at moderate risk for cardiovascular diseases. In a controlled study with 40 participants, we discovered that fish oil supplementation led to significant changes in circulating extracellular vesicles (EVs), which are linked to clotting processes.
Notably, the fish oil reduced the coagulatory activity of these EVs, suggesting a protective effect against thrombus formation. This finding opens up new avenues for preventing blood clots and managing cardiovascular health.
7
Omega-3s may lower clot markers
Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation.
We investigated the link between omega-3 fatty acids and blood clot markers in patients with atrial fibrillation. By analyzing data from over 2,370 participants, we found that higher levels of total omega-3s were connected to lower levels of D-dimer and beta-thromboglobulin, both indicators of activated coagulation and platelet activity.
This suggests that omega-3s may help reduce blood clot risks. However, while some individual fatty acids showed varied effects, the overall trend points to the potential antithrombotic benefits of these healthy fats.
9
FJH-KO reduces blood clots
Antarctic Krill Oil from Ameliorates Carrageenan-Induced Thrombosis in a Mouse Model.
We investigated the impact of FJH-KO, a source of omega-3 fatty acids from Antarctic krill, on thrombosis in a mouse model. By inducing thrombosis using carrageenan, we treated the mice with FJH-KO beforehand.
The results showed that FJH-KO reduced thrombus formation and prolonged bleeding time. It also lowered levels of substances associated with clotting while boosting protective factors. Additionally, in human cells, FJH-KO inhibited the adhesion of immune cells, suggesting its potential as an antithrombotic agent.
9
Omega-3 reduces clot risk post-surgery
Omega-3 fatty acids reduce post-operative risk of deep vein thrombosis and pulmonary embolism after surgery for elderly patients with proximal femoral fractures: a randomized placebo-controlled, double-blind clinical trial.
We explored the impact of omega-3 fatty acids on blood clot risks in elderly patients recovering from proximal femoral fractures after surgery. In a randomized, double-blind study involving 452 participants, those who received daily supplementation of 1000 mg of omega-3 for 30 days experienced significant reductions in pulmonary embolism and symptomatic deep vein thrombosis compared to those on a placebo. Importantly, these benefits came without an increased risk of bleeding complications.
7
Omega-3s reduce thrombin generation
In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi.
We explored the effects of omega-3 fatty acids, specifically docosahexaenoic acid and eicosapentaenoic acid, on blood clotting functions. Using well-designed models, we found that while these omega-3s didn’t significantly alter many platelet functions, they did slow down thrombin generation, a key factor in blood clot formation.
Interestingly, in mice on an omega-3 enriched diet, we observed reduced platelet accumulation in thrombi. This suggests that omega-3 fish oil may indeed have a protective role in cardiovascular health, particularly in moderating blood clot formation.
References
Bozbas E, Zhou R, Soyama S, Allen-Redpath K, Mitchell JL, et al. Dietary n-3 polyunsaturated fatty acids alter the number, fatty acid profile and coagulatory activity of circulating and platelet-derived extracellular vesicles: a randomized, controlled crossover trial. Am J Clin Nutr. 2024;119:1175. 10.1016/j.ajcnut.2024.03.008
Reiner MF, Bertschi DA, Werlen L, Wiencierz A, Aeschbacher S, et al. Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation. Nutrients. 2024;16. 10.3390/nu16020178
Lee GH, Lee SY, Chae JY, Kim JW, Kim JH, et al. Antarctic Krill Oil from Ameliorates Carrageenan-Induced Thrombosis in a Mouse Model. Int J Mol Sci. 2023;24. 10.3390/ijms242417440
Pawelzik SC, Arnardottir H, Sarajlic P, Mahdi A, Vigor C, et al. Decreased oxidative stress and altered urinary oxylipidome by intravenous omega-3 fatty acid emulsion in a randomized controlled trial of older subjects hospitalized for COVID-19. Free Radic Biol Med. 2023;194:308. 10.1016/j.freeradbiomed.2022.12.006
Yamaguchi A, Stanger L, Freedman CJ, Standley M, Hoang T, et al. DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway. J Thromb Haemost. 2021;19:839. 10.1111/jth.15184
Zheng X, Jia R, Li Y, Liu T, Wang Z. Omega-3 fatty acids reduce post-operative risk of deep vein thrombosis and pulmonary embolism after surgery for elderly patients with proximal femoral fractures: a randomized placebo-controlled, double-blind clinical trial. Int Orthop. 2020;44:2089. 10.1007/s00264-020-04610-0
Gaertner S, Auger C, Farooq MA, Pollet B, Khemais-Benkhiat S, et al. Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases. Int J Mol Sci. 2020;21. 10.3390/ijms21030920
Isaksen T, Evensen LH, Brækkan SK, Hansen JB. Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism. Thromb Haemost. 2019;119:2053. 10.1055/s-0039-1697663
Carnevale LN, Das A. Novel Anti-inflammatory and Vasodilatory ω-3 Endocannabinoid Epoxide Regioisomers. Adv Exp Med Biol. 2019;1161:219. 10.1007/978-3-030-21735-8_17
Skulas-Ray AC, Wilson PWF, Harris WS, Brinton EA, Kris-Etherton PM, et al. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association. Circulation. 2019;140:e673. 10.1161/CIR.0000000000000709
Viecelli AK, Polkinghorne KR, Pascoe EM, Paul-Brent PA, Hawley CM, et al. Fish oil and aspirin effects on arteriovenous fistula function: Secondary outcomes of the randomised omega-3 fatty acids (Fish oils) and Aspirin in Vascular access OUtcomes in REnal Disease (FAVOURED) trial. PLoS One. 2019;14:e0213274. 10.1371/journal.pone.0213274
Akintoye E, Sethi P, Harris WS, Thompson PA, Marchioli R, et al. Fish Oil and Perioperative Bleeding. Circ Cardiovasc Qual Outcomes. 2018;11:e004584. 10.1161/CIRCOUTCOMES.118.004584
Spector AA, Kim HY. Emergence of omega-3 fatty acids in biomedical research. Prostaglandins Leukot Essent Fatty Acids. 2019;140:47. 10.1016/j.plefa.2018.11.017
Tam KW, Wu MY, Siddiqui FJ, Chan ES, Zhu Y, et al. Omega-3 fatty acids for dialysis vascular access outcomes in patients with chronic kidney disease. Cochrane Database Syst Rev. 2018;11:CD011353. 10.1002/14651858.CD011353.pub2
Jami MM, Bhardwaj V, Merritt RJ. Intravenous Fish Oil Lipid Emulsion Prevents Catheter-Related Thromboses in Pediatric Patients with Intestinal Failure. J Pediatr. 2018;198:301. 10.1016/j.jpeds.2018.03.029
Adili R, Voigt EM, Bormann JL, Foss KN, Hurley LJ, et al. In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi. Platelets. 2019;30:271. 10.1080/09537104.2017.1420154