We analyzed the effects of fish oil lipid emulsion on the prevention of deep vein thrombosis in children with intestinal failure.
In this study, we compared 35 pediatric patients receiving a soy oil lipid emulsion with 35 who received fish oil.
Remarkably, none of the children in the fish oil group experienced blood clots, whereas the soy oil group had ten cases. This suggests that fish oil lipid emulsion may significantly reduce the risk of clots associated with central venous catheters.
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FJH-KO reduces blood clotsAntarctic Krill Oil from Ameliorates Carrageenan-Induced Thrombosis in a Mouse Model.
High relevance for antithrombotics
We investigated the impact of FJH-KO, a source of omega-3 fatty acids from Antarctic krill, on thrombosis in a mouse model. By inducing thrombosis using carrageenan, we treated the mice with FJH-KO beforehand.
The results showed that FJH-KO reduced thrombus formation and prolonged bleeding time. It also lowered levels of substances associated with clotting while boosting protective factors. Additionally, in human cells, FJH-KO inhibited the adhesion of immune cells, suggesting its potential as an antithrombotic agent.
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DHA's role in blood clottingDHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway.
High relevance in cardiovascular research
We investigated how docosahexaenoic acid (DHA) and its derivatives affect platelet activity and blood clotting. Our findings revealed that DHA, along with its oxidized forms, effectively reduced platelet aggregation and activation, particularly in mouse models.
Although DHA showed some benefits, the most significant effects on blood clots came from its oxylipins, specifically 11-HDHA and 14-HDHA. These compounds appeared to inhibit platelet adhesion and thrombus formation through a specific signaling pathway, enhancing the potential for DHA as a treatment for clot-related cardiovascular issues.
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Omega-3 reduces clot risk post-surgeryOmega-3 fatty acids reduce post-operative risk of deep vein thrombosis and pulmonary embolism after surgery for elderly patients with proximal femoral fractures: a randomized placebo-controlled, double-blind clinical trial.
High relevance for elderly patients
We explored the impact of omega-3 fatty acids on blood clot risks in elderly patients recovering from proximal femoral fractures after surgery. In a randomized, double-blind study involving 452 participants, those who received daily supplementation of 1000 mg of omega-3 for 30 days experienced significant reductions in pulmonary embolism and symptomatic deep vein thrombosis compared to those on a placebo. Importantly, these benefits came without an increased risk of bleeding complications.
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Omega-3s reduce blood clot riskDietary n-3 polyunsaturated fatty acids alter the number, fatty acid profile and coagulatory activity of circulating and platelet-derived extracellular vesicles: a randomized, controlled crossover trial.
High relevance to CVD research
We examined how fish oil, rich in omega-3 polyunsaturated fatty acids (PUFAs), impacts blood clotting in individuals at moderate risk for cardiovascular diseases. In a controlled study with 40 participants, we discovered that fish oil supplementation led to significant changes in circulating extracellular vesicles (EVs), which are linked to clotting processes.
Notably, the fish oil reduced the coagulatory activity of these EVs, suggesting a protective effect against thrombus formation. This finding opens up new avenues for preventing blood clots and managing cardiovascular health.
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